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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PREPL
All Species:
34.85
Human Site:
S450
Identified Species:
69.7
UniProt:
Q4J6C6
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q4J6C6
NP_001035844.1
727
83927
S450
V
L
R
L
E
A
K
S
K
D
G
K
L
V
P
Chimpanzee
Pan troglodytes
XP_001144400
727
83999
S450
V
L
R
L
E
A
K
S
K
D
G
K
L
V
P
Rhesus Macaque
Macaca mulatta
XP_001111959
727
83985
S450
V
L
R
L
E
A
K
S
K
D
G
K
L
V
P
Dog
Lupus familis
XP_531803
727
83861
S450
V
L
R
L
E
A
K
S
K
D
G
K
S
V
P
Cat
Felis silvestris
Mouse
Mus musculus
Q8C167
725
83176
S448
V
L
R
I
E
A
K
S
K
D
G
K
L
V
P
Rat
Rattus norvegicus
Q5HZA6
726
83463
S449
V
L
R
I
E
A
K
S
K
D
G
K
L
V
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521562
342
37329
Y83
K
P
L
L
I
H
V
Y
G
A
Y
G
A
D
L
Chicken
Gallus gallus
Q5ZKL5
732
84295
S466
T
T
R
L
L
A
K
S
K
D
E
T
L
V
P
Frog
Xenopus laevis
Q32N48
707
80150
S429
T
L
R
L
E
A
K
S
K
D
G
T
S
V
P
Zebra Danio
Brachydanio rerio
NP_001139088
692
78210
P429
P
L
T
L
F
H
M
P
A
F
S
E
L
C
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780381
720
80994
S445
C
Q
R
L
V
A
Q
S
Q
D
G
T
N
V
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001151599
784
87028
S522
C
E
R
V
E
V
I
S
H
D
G
V
S
I
P
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99
96.1
N.A.
90.9
90.3
N.A.
26.5
47.5
42
37.9
N.A.
N.A.
N.A.
N.A.
29.3
Protein Similarity:
100
99.7
99.5
98.3
N.A.
95
94.7
N.A.
34.5
66.6
61.4
54.8
N.A.
N.A.
N.A.
N.A.
51.4
P-Site Identity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
6.6
66.6
80
20
N.A.
N.A.
N.A.
N.A.
53.3
P-Site Similarity:
100
100
100
93.3
N.A.
100
100
N.A.
6.6
66.6
80
26.6
N.A.
N.A.
N.A.
N.A.
66.6
Percent
Protein Identity:
N.A.
26.7
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
46.1
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
40
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
53.3
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
75
0
0
9
9
0
0
9
0
0
% A
% Cys:
17
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
84
0
0
0
9
0
% D
% Glu:
0
9
0
0
67
0
0
0
0
0
9
9
0
0
0
% E
% Phe:
0
0
0
0
9
0
0
0
0
9
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
9
0
75
9
0
0
0
% G
% His:
0
0
0
0
0
17
0
0
9
0
0
0
0
0
0
% H
% Ile:
0
0
0
17
9
0
9
0
0
0
0
0
0
9
0
% I
% Lys:
9
0
0
0
0
0
67
0
67
0
0
50
0
0
9
% K
% Leu:
0
67
9
75
9
0
0
0
0
0
0
0
59
0
9
% L
% Met:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% N
% Pro:
9
9
0
0
0
0
0
9
0
0
0
0
0
0
84
% P
% Gln:
0
9
0
0
0
0
9
0
9
0
0
0
0
0
0
% Q
% Arg:
0
0
84
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
84
0
0
9
0
25
0
0
% S
% Thr:
17
9
9
0
0
0
0
0
0
0
0
25
0
0
0
% T
% Val:
50
0
0
9
9
9
9
0
0
0
0
9
0
75
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
9
0
0
9
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _